Lamin a c is a type v nuclear lamin.
What is lamin a c.
Nuclear lamins a b1 b2 and c.
Haplo insufficiency in the cardiomyocyte nuclei.
During apoptosis lamin a c is specifically cleaved into a large 41 50 kda and a small 28 kda fragment 3 4.
Biogenesis of lamin a in normal cells and the failure to generate mature lamin a in hutchinson gilford progeria.
Lamin a c belongs to the lamin family of proteins.
The lamin a protein must be processed within the cell before becoming part of the lamina.
Lamin c does not have to undergo this processing before becoming part of the lamina.
Two isoforms lamins a and c can be created from this gene via alternative splicing.
Lamin a was detected in 10 to 20 of hgps lymphocytes.
Lamins a and c are identical for the first 566 amino acids with lamin c differing only in six unique carboxy terminal amino acids.
290 the transcript from the gene is spliced differentially to give rise to the two different forms lamin a and lamin c.
17 37 this is due to either the degradation of the mutated mrna carrying a premature stop codon via the non sense mediated decay pathway or to the degradation of the corresponding truncated lamin.
Not intended for diagnostic or therapeutic use.
Lamin a c expression explored in various explanted heart tissues from patients carrying nonsense lmna mutations revealed reduced lamin a c level i e.
The cleavage of lamins results in nuclear dysregulation and cell death 5 6.
During apoptosis lamin a c is specifically cleaved into a large 41 50 kda and a small 28 kda fragment 3 4.
Lamin a c is an intermediate filament lining the inner nuclear membrane part of the nuclear envelope.
For research use only.
Western blot analysis showed 25 of normal lamin a levels and no truncated form was detected.
Prelamin a and lamin c differ in structure only at the carboxyl terminus.
Lamin a c is cleaved by caspase 6 and serves as a marker for caspase 6 activation.
Lmna also known as lamin a c is a protein that in humans is encoded by the lmna gene.
The lamins are components of the nuclear lamina a fibrous layer on the nucleoplasmic side of the inner nuclear membrane which is suggested to provide a framework for the nuclear envelope and may interact with chromatin.
Lamin a c is cleaved by caspase 6 and serves as a marker for caspase 6 activation.
Unlike lamin c lamin a is generated in a precursor form called prelamin a.
The cleavage of lamins results in nuclear dysregulation and cell death 5 6.
Lamin c is a splice variant of lamin a differing only at the carboxy terminus.
